15
BP-03 | LITERATURE ANALYSIS
BP-03: potential pragmatic exclusions for controlled hypotension
Source(s) Key finding from review Implication for measure
D'Amico et al.
BJA 2023
Meta-analysis of 10 randomized trials (9,359 patients): a
MAP target of 60 mmHg was not associated with increased
mortality; some secondary outcomes favored the lower-
target group.
Suggests mild controlled hypotension can be
tolerated in selected populations, but does not
establish universal safety.
Dauterman et al.
BJA 2024
Meta-analysis of 48 RCTs: controlled hypotension reduced
blood loss, but trials were not adequately powered to
evaluate MI, AKI, or other major safety outcomes.
As above, demonstrated efficacy for surgical
benefits without evidence (positive or negative) re:
safety.
Orthopedic / OMFS /
ENT literature
Studies report reduced blood loss, improved visualization,
shorter operating time or LOS in selected procedures;
samples are generally too small and heterogeneous to
establish impact on safety outcomes.
Many clinicians target a MAP in the 60-65 range for
patients without risk factors, which BP-03 classifies
as noncompliant despite a deliberate protocol.
Trauma literature
In selected hemorrhagic trauma without TBI, early
hypotensive resuscitation has shown benefit in randomized
data.
Illustrates evidence-based benefit rather than
quality metric failure.
Selected references
D'Amico F et al. Br J Anaesth. 2023;131:823–831. | Dauterman L et al. Br J Anaesth. 2024;133:940–954. | Zhang QY et al. Orthop Surg. 2022;14:555–565. | Ji J et al. BMC Surg. 2026;26:509. | Carrick MM et al. J Trauma Acute
Care Surg. 2016;80:886–896.